TABLE 1.

Drugs and main reagents.

Reagent name	Manufacturer/Item number	Lot/Catalog number
Seawater pearl powder (cultured Pinctada martensii)	Beihai baozhulin MarineTechnology Co., ltd	450522020014
Kuntai capsules	Guiyang xintian pharmaceutical Co., ltd	220903
Penicillin sodium for injection	Shandong shengwang pharmaceutical Co., ltd	20211101
Neutral protease	Beijing Solarbio science & technology Co., ltd	3424080827
Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), testosterone (T), progesterone (P) and (anti-müllerian hormone) AMH ELISA kits	Shanghai Jianglai biotechnology Co., ltd.; jiangsu enzyme immunoassay industrial Co., ltd	JL13251、JL21049、JL11473、MM-0219R6、MM-0219R1、MM-0575R11
Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) ELISA kits	Nanjing jiancheng technology Co., ltd	A111-1-1、A110-1-1、A113-1-1、A112-1-1
Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) ELISA kits	Nanjing jiancheng technology Co., ltd	H052-1-1、H002-1-2、H007-1-1
Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase	W nanjing jiancheng technology Co., ltd	A003-1-2、A001-3-2
TRIpure total RNA extraction reagent	ELK biotechnology Co., ltd	EP013
Hematoxylin and eosin (H&E) staining kit	Beijing Solarbio science & technology Co., ltd	C0105
Reverse transcription kit, quantitative real-time PCR kit	Wuhan aspen biotechnology Co., ltd	MR05101、MQ00701
RIPA lysis buffer, BCA protein assay kit, phosphatase inhibitor cocktail, ECL chemiluminescence detection kit; HRP-conjugated goat anti-rabbit/anti-mouse secondary antibodies	Wuhan aspen biotechnology Co., ltd	AS1004、AS1086、AS1008、AS1059、AS1114、AS1093
ERα, GAPDH primary antibodies	Abcam (shanghai) trading Co., ltd	ab32063、ab181602
MAP2K1 primary antibody	Wuhan sanying biotechnology Co., ltd	67872-1-Ig
p-ERK, p-CREB primary antibodies	Cell signaling technology (CST)/Shanghai nuoning biotechnology Co., ltd	4370、9198