Fig. 2. Click-handle containing BCN PD 1 (5 step synthesis from 1-boc-1-methylhydrazine; this compound is also available commercially from various suppliers (e.g. Merck and Precise PEG)), ArN3 bisPD 2 (8 step synthesis from 1,2-diboc-hydrazine (di-tert-butyl hydrazodiformate); that said, many intermediates in the synthesis are commercially available) and N3 aniline 3 (5 step synthesis from para-aminophenol and tetraethylene glycol), and model PDs diEt PD 4 (2 step synthesis from 1,2-diboc-hydrazine (di-tert-butyl hydrazodiformate)) and diMe bisPD 5 (4 step synthesis from 1-boc-1-methylhydrazine; this compound is also available commercially from Precise PEG). For full synthetic schemes, see SI Fig. S1–S5. Note: many synthetic steps are common in the synthesis of the various PDs.
