Table 2. Descriptive analysis of CoR familial Mediterranean fever patients (n=118).
| Characteristics of CoR patients | All CoR (n=118) | Paediatric diagnostic (n=85) |
Adult diagnostic (n=33) | P value paediatric versus adult |
|---|---|---|---|---|
| Female, n (%) | 67 (56.8) | 34 (40) | 17 (51.52) | 0.354 |
| Age at symptom onset, mean (SD) (years) | 4.93 (4.81) | 3.84 (3.54) | 7.74 (6.41) | <0.001 |
| Age at first symptoms ≤3 years, n (%) | 52 (44.1) | 46 (54.12) | 6 (18.18) | <0.001 |
| Age at diagnosis, mean (SD) (years) | 14.14 (13.87) | 6.78 (4.64) | 33.08 (11.81) | – |
| Attack duration, mean (SD) (days) | 2.83 (1.2) | 2.65 (1.01) | 3.29 (1.53) | 0.008 |
| Parental consanguinity, n (%) (data availability) | 13 (12.9) (101/118) | 9 (12) | 4 (15.38) | 0.736 |
| Homozygosity or compound heterozygosity for exon 10 MEFV variants, n (%) | 118 (100%) | 82 (100) | 34 (100) | – |
| Frequency of attacks ≥1 per month, n (%) | 91 (77.1) | 71 (83.53) | 20 (60.61) | 0.013 |
| Clinical findings before diagnosis, n (%) | ||||
| Fever ELE Arthralgia Arthritis Abdominal pain Chest pain |
101 (85.6) 56 (47.5) 95 (80.5) 48 (40.7) 113 (95.8) 51 (43.2) |
74 (87.0) 41 (48.2) 67 (78.8) 35 (41.2) 81 (95.3) 40 (47.1) |
27 (81.8) 15 (45.5) 28 (84.9) 13 (39.4) 33 (97) 11 (33) |
0.56 0.947 0.607 >0.999 >0.999 0.253 |
| TURPAID score, mean (SD) | 2.73 (0.69) | 2.84 (0.692) | 2.45 (0.63) | 0.011 |
| Patients with TURPAID score ≥2, n (%) | 111 (94.1) | 82 (96.47) | 29 (87.88) | 0.095 |
Variables in bold are statistically significant.
CoR, colchicine-resistant; ELE, erysipela-like erythema; TURPAID, Turkish Paediatric Autoinflammatory Diseases.