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. 2026 Feb 16;32(2):591–598. doi: 10.1038/s41591-025-04154-z

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CONSORT diagram showing participant screening, randomization, dosing and follow-up. Of 399 individuals prescreened, 34 met inclusion criteria and were randomized (AA, n = 17; PA, n = 17). Two participants withdrew before completion. Four in the AA arm declined a second dose but completed follow-up. The diagram details attrition and numbers analyzed at each study stage. Each participant represents one independent biological replicate. CONSORT, Consolidated Standards of Reporting Trials.