TABLE 6.
Multivariate Cox regression analysis of MACE risk in patients with different CYP2C19 metabolizers.
| Metabolic type | Variable | HR | 95%CI | P值 |
|---|---|---|---|---|
| EM type | Tica. (vs. Clop.) | 1.05 | 0.36–3.02 | 0.931 |
| Age (for each additional year) | 1.02 | 0.96–1.09 | 0.512 | |
| Gender (M vs. F) | 1.21 | 0.41–3.59 | 0.731 | |
| Hypertension (yes vs. no) | 1.35 | 0.45–4.08 | 0.592 | |
| Diabetes (yes vs. no) | 1.58 | 0.52–4.76 | 0.416 | |
| Smoking (yes vs. no) | 1.12 | 0.38–3.31 | 0.836 | |
| IM type | Tica. (vs. Clop.) | 0.52 | 0.28–0.98 | 0.043 |
| Age (for each additional year) | 1.03 | 0.99–1.07 | 0.105 | |
| Gender (M vs. F) | 1.18 | 0.64–2.18 | 0.601 | |
| Hypertension (yes vs. no) | 1.29 | 0.69–2.41 | 0.426 | |
| Diabetes (yes vs. no) | 1.45 | 0.78–2.70 | 0.241 | |
| Smoking (yes vs. no) | 1.09 | 0.59–2.01 | 0.782 | |
| PM type | Tica. (vs. Clop.) | 0.32 | 0.11–0.89 | 0.029 |
| Age (for each additional year) | 1.04 | 0.97–1.12 | 0.279 | |
| Gender (M vs. F) | 1.41 | 0.55–3.62 | 0.473 | |
| Hypertension (yes vs. no) | 1.62 | 0.63–4.17 | 0.318 | |
| Diabetes (yes vs. no) | 1.78 | 0.69–4.55 | 0.230 | |
| Smoking (yes vs. no) | 0.85 | 0.33–2.17 | 0.730 |
MACE, major adverse cardiovascular event;HR, hazard ratio; CI, confidence interval. Analysis was based on propensity score-matched cohort and adjusted for covariates listed in table.