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Alignment of Ire1 homologs from various organisms. Two Arabidopsis homologs (AtIre1-1 and AtIre1-2; this study), yeast Ire1p (Ire1p, accession no. Z11701), human Ire1α (hIre1α, accession no. AF059198), and mouse Ire1β (mIre1β, accession no. AF071777) were aligned using ClustalW software. Amino acid residues conserved in three out of five sequences are boxed. The ATP binding motif (VAVKR) and the Ser/Thr protein kinase motif (DLKPQN) are underlined.
