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. 2026 Feb 9;17:1748950. doi: 10.3389/fphar.2026.1748950

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Copyright © 2026 Hakim, Habashy, Ascenção, Youness, Bourquin, Szabo, Gad and Abdelkader.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart diagram illustrating the synthesis and metabolism of hydrogen sulfide (H₂S) in mitochondria, with labeled pathways, enzymes, and downstream effects on cell survival, growth, and proliferation through PI3K, AKT, and mTORC1 signaling. — Synthesis and metabolism of H₂S, with a special emphasis on 3-MST and signaling pathways involved in cell growth and proliferation.