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. 2026 Feb 9;17:1748950. doi: 10.3389/fphar.2026.1748950

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Copyright © 2026 Hakim, Habashy, Ascenção, Youness, Bourquin, Szabo, Gad and Abdelkader.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar graphs and a Western blot image showing the effects of various treatments on protein expression. Graphs A to E display relative expression levels of CBS, CSE, 3-MST, TST, and ETHE1 across different treatments: CTR, Dox 1µM, Dox+HMPSNE, and HMPSNE 100µM. Significant changes are marked with asterisks. Graph F shows a Western blot with bands for CBS, CSE, 3-MST, TST, ETHE1, and β-Actin under different treatment conditions: Control, Dox, Dox+HMPSNE, and HMPSNE. — Effects of HMPSNE and/or doxorubicin on the expression of H₂S-synthesizing and H₂S-metabolizing enzymes. (A–E) show the quantification of the Western blot densitometry; (F) shows representative Western blots. The data are shown as the means ± SEMs of four independent experiments: * = P < 0.05, ** = P < 0.01 compared with the untreated control.