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. 2026 Feb 9;17:1748950. doi: 10.3389/fphar.2026.1748950

FIGURE 6.

A four-part figure showing the effect of treatments on cancer cells. A) Bar graphs displaying the number of colonies of MDA-MB-231 cell under different treatment conditions: control, Dox, Dox+HMPSNE, and HMPSNE conditions. B) Images of cell cultures showing the colonies conditions the same conditions. C) Bar graph illustrating percent cell migration with the same treatments. D) Microscopic images showing cell migration in control, Dox, HMPSNE, and Dox plus HMPSNE groups. Statistical significance is indicated by asterisks.

Effects of HMPSNE (100 µM) alone or in combination with doxorubicin (1 µM) on the clonogenicity and migration of MDA-MB-231 cells. (A,C) Compared with the doxorubicin- or HMPSNE-treated groups, the combination group presented a significant reduction in the number of colonies formed and in the degree of cellular migration. Compared with the control, doxorubicin significantly reduced the number of formed colonies and the degree of cellular migration. (B,D) Representative images of the plates and transwells. The data are presented as the means ± SEMs of three independent experiments: *P < 0.05 and **P < 0.01 indicate statistically significant differences between the indicated groups.