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. 2026 Feb 9;17:1748950. doi: 10.3389/fphar.2026.1748950

FIGURE 8.

Five bar graphs labeled A through E display relative protein expression levels for AKT, phosphorylated AKT, GSK-3β, mTOR, and phosphorylated mTOR under different treatments: Control, Dox, Dox plus HMPSNE, and HMPSNE. Statistically significant changes are indicated in some groups. Panel F shows a Western blot with corresponding protein bands for each treatment condition, including controls for protein loading and molecular weights.

Effects of HMPSNE (100 µM) alone or in combination with doxorubicin (1 µM) on AKT, GSK-3β and mTOR expression in MDA-MB-231 cells. (A–E) show the quantification of the Western blot densitometry; (F) shows representative Western blots. The data are shown as the means ± SEMs of four independent experiments: * = P < 0.05, ** = P < 0.01 compared with the untreated control.