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. 2026 Feb 10;13:1707450. doi: 10.3389/fnut.2026.1707450

Figure 2.

Six line graphs labeled A to F show restricted cubic splines for different biomarkers: Apolipoprotein A, Apolipoprotein B, Cholesterol, HDL Cholesterol, LDL Direct, and Triglycerides. Each graph displays a curve with confidence intervals, indicating the relationship between each biomarker and a chosen outcome. Graphs A, C, D, and F depict a downward trend, while B and E show a less pronounced change. Statistical significance values (Overall and Nonlinear P) are noted on each graph.

Restricted cubic spline models depicting the dose-response relationship of serum lipids with the risk of DLBCL. The analysis is presented for apolipoprotein A (A), apolipoprotein B (B), total cholesterol (C), high-density lipoprotein (HDL) (D), low-density lipoprotein (LDL) (E), and triglycerides (F). All models were adjusted for age, sex, ethnicity, BMI, TDI, education level, smoking status, alcohol consumption, physical activity, history of diabetes, history of hypertension, and medication use.