Table 2.
Associations between serum lipid and the risk of DLBCL in the UK Biobank.
| Variable | Model 1 | P | Model 2 | P | Model 3 | P | FDR |
|---|---|---|---|---|---|---|---|
| ApoA (continuous) | 0.42 (0.34, 0.53) | < 0.001 | 0.41 (0.32, 0.53) | < 0.001 | 0.42 (0.32, 0.54) | < 0.001 | 0.006 |
| ApoA quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 0.76 (0.66, 0.88) | < 0.001 | 0.76 (0.65, 0.88) | < 0.001 | 0.76 (0.66, 0.89) | < 0.001 | |
| Q3 | 0.69 (0.59, 0.81) | < 0.001 | 0.69 (0.59, 0.81) | < 0.001 | 0.70 (0.59, 0.82) | < 0.001 | |
| Q4 | 0.55 (0.46, 0.64) | < 0.001 | 0.54 (0.45, 0.65) | < 0.001 | 0.55 (0.46, 0.66) | < 0.001 | |
| ApoB (continuous) | 0.87 (0.68, 1.10) | 0.246 | 0.86 (0.68, 1.09) | 0.216 | 0.80 (0.62, 1.03) | 0.084 | 0.101 |
| ApoB quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 0.93 (0.80, 1.09) | 0.383 | 0.96 (0.82, 1.13) | 0.641 | 0.94 (0.80, 1.11) | 0.469 | |
| Q3 | 0.93 (0.79, 1.08) | 0.338 | 0.93 (0.79, 1.09) | 0.371 | 0.90 (0.76, 1.06) | 0.194 | |
| Q4 | 0.94 (0.80, 1.10) | 0.427 | 0.93 (0.79, 1.08) | 0.335 | 0.88 (0.75, 1.04) | 0.146 | |
| HDL (continuous) | 0.48 (0.41, 0.57) | < 0.001 | 0.52 (0.43, 0.63) | < 0.001 | 0.51 (0.42, 0.62) | < 0.001 | 0.012 |
| HDL quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 0.66 (0.57, 0.77) | < 0.001 | 0.68 (0.59, 0.79) | < 0.001 | 0.68 (0.58, 0.79) | < 0.001 | |
| Q3 | 0.63 (0.54, 0.73) | < 0.001 | 0.67 (0.57, 0.79) | < 0.001 | 0.67 (0.57, 0.79) | < 0.001 | |
| Q4 | 0.52 (0.44, 0.61) | < 0.001 | 0.56 (0.47, 0.67) | < 0.001 | 0.56 (0.46, 0.67) | < 0.001 | |
| LDL (continuous) | 0.91 (0.85, 0.97) | 0.005 | 0.93 (0.87, 1.00) | 0.037 | 0.91 (0.84, 0.97) | 0.008 | 0.012 |
| LDL quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 0.95 (0.82, 1.11) | 0.540 | 1.05 (0.90, 1.22) | 0.555 | 1.01 (0.86, 1.18) | 0.930 | |
| Q3 | 0.79 (0.67, 0.92) | 0.003 | 0.84 (0.71, 0.99) | 0.035 | 0.80 (0.67, 0.95) | 0.010 | |
| Q4 | 0.89 (0.76, 1.04) | 0.128 | 0.92 (0.79, 1.08) | 0.308 | 0.87 (0.73, 1.03) | 0.108 | |
| TC (continuous) | 0.88 (0.83, 0.92) | < 0.001 | 0.90 (0.86, 0.95) | < 0.001 | 0.88 (0.83, 0.93) | < 0.001 | 0.012 |
| TC quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 0.90 (0.78, 1.05) | 0.191 | 1.01 (0.87, 1.18) | 0.884 | 0.97 (0.82, 1.13) | 0.676 | |
| Q3 | 0.75 (0.64, 0.88) | < 0.001 | 0.82 (0.70, 0.96) | 0.015 | 0.78 (0.65, 0.92) | 0.003 | |
| Q4 | 0.73 (0.63, 0.86) | < 0.001 | 0.78 (0.65, 0.91) | 0.002 | 0.73 (0.61, 0.87) | < 0.001 | |
| TG (continuous) | 1.07 (1.01, 1.12) | 0.022 | 1.00 (0.94, 1.06) | 0.97 | 0.98 (0.92, 1.04) | 0.564 | 0.564 |
| TG quartile | |||||||
| Q1 | Ref | Ref | Ref | ||||
| Q2 | 1.15 (0.98, 1.37) | 0.093 | 0.97 (0.82, 1.15) | 0.755 | 0.96 (0.81, 1.13) | 0.610 | |
| Q3 | 1.34 (1.14, 1.57) | < 0.001 | 1.05 (0.89, 1.24) | 0.552 | 1.02 (0.86, 1.20) | 0.845 | |
| Q4 | 1.26 (1.07, 1.49) | 0.006 | 0.98 (0.83, 1.15) | 0.790 | 0.93 (0.78, 1.11) | 0.431 | |
ApoA, apolipoprotein A; ApoB, apolipoprotein B; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides. Model 1 was an unadjusted crude model; Model 2 was adjusted for age, sex, and ethnicity; and Model 3 was further adjusted for BMI, TDI, education level, smoking status, alcohol consumption, physical activity, history of diabetes, history of hypertension, and medication use.