Table 2.
Association of baseline serum β-synuclein levels with future cognitive decline
| MMSE | CDR-SB | |||||
|---|---|---|---|---|---|---|
| rs-value | p-value | N | rs-value | p-value | N | |
| All | ||||||
| BL | −0.450 | 9.09E-22 | 409 | 0.468 | 1.27E-23 | 409 |
| Year 1 | −0.472 | 1.11E-22 | 383 | 0.486 | 4.95E-24 | 382 |
| Year 2 | −0.517 | 1.48E-21 | 295 | 0.490 | 1.01E-20 | 320 |
| Year 3 | −0.393 | 8.29E-09 | 200 | 0.443 | 1.19E-11 | 213 |
| Year 4 | −0.502 | 8.66E-10 | 132 | 0.422 | 3.66E-08 | 157 |
| Year 5 | −0.447 | 1.38E-07 | 127 | 0.443 | 4.31E-08 | 140 |
| RoC | −0.352 | 2.28E-13 | 409 | 0.410 | 5.37E-18 | 409 |
| AD | ||||||
| BL | −0.074 | 4.08E-01 | 127 | 0.056 | 5.30E-01 | 127 |
| Year 1 | −0.165 | 7.11E-02 | 120 | 0.135 | 1.42E-01 | 120 |
| Year 2 | −0.114 | 2.86E-01 | 90 | 0.123 | 2.32E-01 | 96 |
| Year 3 | 0.522 | 4.79E-02 | 15 | −0.185 | 4.23E-01 | 21 |
| Year 4 | −0.422 | 2.98E-01 | 8 | −0.046 | 8.97E-01 | 11 |
| Year 5 | 0.400 | 7.50E-01 | 4 | −0.030 | 1.00E + 00 | 6 |
| RoC | −0.147 | 9.91E-02 | 127 | 0.208 | 1.88E-02 | 127 |
| MCI | ||||||
| BL | −0.316 | 5.76E-05 | 156 | 0.195 | 1.48E-02 | 156 |
| Year 1 | −0.330 | 5.82E-05 | 143 | 0.256 | 2.15E-03 | 142 |
| Year 2 | −0.485 | 2.02E-07 | 103 | 0.292 | 1.56E-03 | 115 |
| Year 3 | −0.391 | 2.01E-04 | 86 | 0.415 | 2.84E-05 | 95 |
| Year 4 | −0.582 | 1.35E-06 | 59 | 0.406 | 2.30E-04 | 78 |
| Year 5 | −0.431 | 3.02E-04 | 66 | 0.470 | 5.15E-05 | 68 |
| RoC | −0.360 | 3.84E-06 | 156 | 0.295 | 1.88E-04 | 156 |
| CU | ||||||
| BL | 0.031 | 7.30E-01 | 126 | 0.101 | 2.61E-01 | 126 |
| Year 1 | −0.102 | 2.67E-01 | 120 | 0.093 | 3.13E-01 | 120 |
| Year 2 | −0.138 | 1.66E-01 | 102 | 0.037 | 7.04E-01 | 109 |
| Year 3 | −0.028 | 7.82E-01 | 99 | 0.048 | 6.39E-01 | 97 |
| Year 4 | −0.120 | 3.42E-01 | 65 | −0.048 | 6.96E-01 | 68 |
| Year 5 | −0.222 | 9.73E-02 | 57 | 0.136 | 2.77E-01 | 66 |
| RoC | −0.094 | 2.93E-01 | 126 | 0.070 | 4.37E-01 | 126 |
Correlation analyses were performed using Spearmans rank correlation coefficient (rs). Significant correlations are indicated in bold
AD Alzheimer´s disease, BL Baseline visit, CDR-SB Clinical dementia rating sum-of-boxes, CU Cognitively unimpaired, MCI Mild cognitive impairment, MMSE Mini-Mental State Examination, RoC Rate-of-change