Table 3.

Correlation of serum β-synuclein with other fluid biomarkers

	Serum β-Syn	MMSE	CDR-SB	CSF Aβ42	CSF tTau	CSF pTau181	Plasma NfL	CSF NfL	CSF NRGN
Serum β-Syn		−0.467****	0.486****	−0.454****	0.422****	0.453****	0.493****	0.202*	0.398****
MMSE	n = 463		−0.783****	0.428****	−0.248***	−0.273***	−0.424****	−0.338****	−0.213**
CDR-SB	n = 461	n = 461		−0.493****	0.406****	0.422****	0.448****	0.427****	0.345****
CSF Aβ42	n = 194	n = 194	n = 194		−0.144*	−0.237***	−0.23**	−0.153	−0.103
CSF tTau	n = 194	n = 194	n = 194	n = 194		0.981****	0.167*	0.368****	0.849****
CSF pTau181	n = 194	n = 194	n = 194	n = 194	n = 194		0.169*	0.339****	0.82****
Plasma NfL	n = 248	n = 248	n = 247	n = 156	n = 156	n = 156		0.563****	0.108
CSF NfL	n = 155	n = 155	n = 155	n = 152	n = 152	n = 152	n = 154		0.167*
CSF NRGN	n = 148	n = 148	n = 148	n = 145	n = 145	n = 145	n = 147	n = 148

Correlation analyses were performed using Spearmans rank correlation coefficient. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

CDR-SB Clinical dementia rating sum-of-boxes, MMSE Mini-Mental State Examination, pTau181, tau protein phosphorylated at S181, tTau total tau protein, NfL Neurofilament light chain, NRGN Neurogranin