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. 2002 Aug 23;99(18):11593–11598. doi: 10.1073/pnas.182256799

Scheme 2.

Scheme 2

Model for the activation and repression of gene transcription involving the accessory role of NM23-H2 in interconversion of the unstructured purine and pyrimidine single-stranded DNA forms to the paranemic secondary DNA structures. Interaction of the G-quadruplex structure with TMPyP4 stabilizes the gene-off form by inhibition of conversion to the single-stranded gene-on forms (see text for further details).