Table 2.
ICU characteristics and adverse events related to daptomycin.
| ICU stay | No TDM (n = 145) | TDM (n = 125) | p-value |
|---|---|---|---|
| ICU characteristics | |||
| SOFA score | 10 (8–13) | 10 (8–12) | 0,45 |
| SAPS II score | 45 (32–57) | 36 (28–53) | 0,031 |
| CRRT | 129 (88.9) | 111 (88.8) | 1,000 |
| iHD | 12 (8.3) | 13 (10.4) | 0,674 |
| SLED | 13 (8.9) | 10 (8) | 0,830 |
| ECMO | 22 (15.2) | 16 (12.8) | 0,603 |
| ICU death | 57 (39.3) | 56 (44.8) | 0,388 |
| In-hospital death | 90 (62.1) | 91 (72.8) | 0,070 |
| ICU length of stay (days) | 15 (7–28) | 18 (10–32) | 0,027 |
| Adverse events | |||
| High CK levels | 30 (20.7) | 28 (22.4) | 0,334 |
| Eosinophilia | 16 (11) | 23 (18.4) | 0,047 |
| High CK levels + Eosinophilia | 9 (6.2) | 7 (5.6) | 0,813 |
Categorical numbers are reported as count and (percentages). Continuous variables are reported as median and (interquartile range (IQR)). CK, Creatine kinase; CRRT, Continuous renal replacement therapy; ECMO, Extracorporeal membrane oxygenation; ICU, Intensive care unit; iHD, Intermittend hemodialysis; SAPS, Simplified acute physiology score; SLED, Sustained low efficiency dialysis; SOFA, Sequential organ failure assessment.