Figure 2.

Endogenous factor (F)IX activity (A) over the 4-year follow-up and (B) as a function of baseline adeno-associated viral vector serotype 5 (AAV5) neutralizing antibody titer. The latter was calculated for the entire posttreatment period (months 7-48). Horizontal lines within the boxes in A depict medians, bars depict upper and lower quartiles (quartiles 1-3), and diamonds show individual levels of expression at years 1 to 4. aPTT, activated partial thromboplastin time; rp, Pearson product-moment correlation coefficient; rs, Spearman correlation coefficient.