Table 1:
Dosing schemes for oral gavage FMT from rodent conspecifics in stress-related behavioral models
| Disorder Investigated | Animal Model | Timeline/Duration | Microbial Content | Dose | Reference |
|---|---|---|---|---|---|
| Chronic Stress | mouse | 1 and 4 days after antibiotic discontinuation (2 doses total) | 1 mg feces in 5 mL PBS (phosphate buffer saline) | 300 uL | (Siopi et al., 2020) |
| Depression | mouse | 1x/day for 3 consecutive days (3 doses total) | ~2 × 108 viable probiotic fecal bacteria in PBS | 300 uL | (Zhang et al., 2019) |
| Chronic unpredictable mild stress | mouse | 1x/2 days for 14 days (7 doses) | Supernatant of cecal content diluted 40-fold in PBS | 200 uL | (Li et al., 2019) |
| Alcohol withdrawal-induced anxiety | mouse | 1x/day for 14 consecutive days (14 doses total | Supernatant of 0.1g feces in 1mL saline | 200 uL | (Xiao et al., 2018) |
| Depression | rat | 1x/3 days for 16 days (6 doses total) | 1 g feces in 5 mL saline | 750 uL | (Tillmann et al., 2019) |
| Depression | rat | 1x for 3 days (3 doses) | 1g feces in 15 mL PBS | 200 uL | (Lv et al., 2019) |
| Social defeat | rat | 1x/5 days (5 doses) | 5 mg feces in 1 mL PBS | 2 mL | (Pearson-Leary et al., 2020) |