Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A state of refractoriness limits the magnitude of the CD8+ T cell response despite repeated exposure to bites of infected mosquitoes. Normal mice were immunized every 48 h with two bites of irradiated infected mosquitoes. The frequencies of epitope-specific CD8+ T cells in the spleens were measured by ELISPOT 16 days after the first immunization. Results represent one of three similar experiments expressed as mean + SD.
