TABLE 1.

Summary of genes identified from a Southern Indian OSCC cohort (Paul et al., 2025) that harbor SNPs associated with chemotherapeutic drug-response according to ClinPGx. For each gene, the corresponding drug(s) and associated SNPs are shown, representing the initial gene–drug–variant space from which the structurally analyzable SNPs were subsequently filtered.

Genes a	SNPs	Drugs
EGFR	rs2293347and rs2227983	Imatinib, cetuximab, EGFR inhibitors, fluorouracil, and gefitinib
TP53	rs1042522	Platinum compounds, antineoplastic agents, capecitabine, paclitaxel, cisplatin, and oxaliplatin
ERCC5	rs1047768and rs17655	Fluorouracil, platinum compounds, radiotherapy, and platinum
ERCC2	rs1799793	Bevacizumab, bleomycin, capecitabine, cisplatin, docetaxel, epirubicin, etoposide, fluorouracil, gemcitabine, oxaliplatin, platinum compounds, radiotherapy, and trastuzumab
DHFR/MSH3	rs1650697	Pemetrexed
RET	rs1799939	Imatinib
ATM	rs1801516	Cyclophosphamide, doxorubicin, and fluorouracil
KDR	rs1870377 and rs2305948	Cisplatin, fluorouracil, oxaliplatin, imatinib, sorafenib, and sunitinib
FLT3	rs1933437	Imatinib and sunitinib
XPC	rs2228000 and rs2228001	Platinum compounds
ERBB2	rs1136201	Carboplatin, docetaxel, and trastuzumab
ERBB3	rs773123	Carboplatin, docetaxel, and trastuzumab
XRCC1	rs1799782 and rs25487	Carboplatin, cisplatin, cyclophosphamide, doxorubicin, fluorouracil, irinotecan, leucovorin, oxaliplatin, platinum, platinum compounds, and radiotherapy
MUTYH	rs3219489	Cisplatin, fluorouracil, and radiotherapy
FGFR4	rs351855	Cyclophosphamide, fluorouracil, methotrexate, and everolimus
PDGFRA	rs35597368	Imatinib
FLT1	rs7993418	Cisplatin, fluorouracil, oxaliplatin, and imatinib

^a Genes were curated from Paul et al.(2025) (data available at https://bcga.iitm.ac.in/cbioportal/study/summary?id=HNSCC_Yenepoya_2025) and annotated with drug-variant information from ClinPGx.