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(A) Comparison by reverse transcription–PCR of PPARα mRNA in the liver of a wild-type (+/+) and a PPARα knockout (−/−) mouse. (B) The appearance of adipose tissue in a PPAR+/+ and a PPAR−/− mouse 7 days after the induction of hyperleptinemia by the i.v. administration of AdCMV-leptin.
