Table 1.
Baseline characteristics of total cohort and derivatives. Continuous data are presented in median (interquartile range). Categorical data are presented as absolute numbers (percentage) of participants. Mann–Whitney U or Chi-squared test were used as appropriate. Abbreviations: ADP, adenosine diphosphate; aspirin, acetylsalicylic acid; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NIHSS, National Institute of Health Stroke Scale; mRS, modified Rankin Scale. *p < 0.05, **p < 0.01, ***p < 0.001
| Baseline characteristics of patients from the MARK-STROKE cohort | |||
|---|---|---|---|
| Characteristics | Aspirin, yes (n = 270) |
Aspirin, no (n = 104) |
p-value |
| Demographics | |||
| Age—years | 68.0 (57.0; 77.0) | 72.0 (61.3; 81.0) | 0.051 |
| Male sex—no. (%) | 171 (63.3) | 71 (68.3) | 0.371 |
| Body mass index—kg/m2 | 25.8 (23.7; 28.4) | 25.4 (23.2; 28.4) | 0.629 |
| Vascular risk factors | |||
| Current smoking—no. (%) | 69 (25.5) | 25 (24.0) | 0.762 |
| Hypertension—no. (%) | 195 (72.2) | 77 (74.0) | 0.724 |
| Hyperlipidemia—no. (%) | 91 (33.7) | 30 (28.8) | 0.368 |
| Diabetes mellitus—no. (%) | 51 (18.9) | 13 (12.5) | 0.142 |
| Atrial fibrillation—no. (%) | 26 (9.6) | 59 (56.7) | < 0.001*** |
| Prior myocardial infarction—no. (%) | 40 (14.8) | 5 (4.8) | < 0.001*** |
| Prior stroke—no. (%) | 43 (15.9) | 19 (18.3) | 0.585 |
| Laboratory | |||
| Hematocrit—% | 40.8 (37.3; 44.3) | 40.0 (36.6; 42.7) | 0.182 |
| Leucocytes—109/L | 7.30 (5.88; 8.73) | 7.75 (6.13; 9.98) | 0.073 |
| Platelets—109/L | 238.5 (195.0; 287.3) | 232.5 (174.3; 269.5) | 0.110 |
| HbA1c—% | 5.7 (5.4; 6.1) | 5.7 (5.4; 5.9) | 0.708 |
| Triglycerides—mg/dL | 130.0 (92.5; 179.5) | 108.5 (88.0; 151.5) | 0.008** |
| HDL-cholesterol—mg/dL | 49.0 (40.0; 60.0) | 49.5 (38.0; 59.0) | 0.525 |
| LDL-cholesterol—mg/dL | 106.0 (77.5; 136.0) | 102.0 (74.5; 131.5) | 0.445 |
| Creatinine—mg/dL | 0.88 (0.74; 1.10) | 0.96 (0.82; 1.18) | 0.031* |
| Sphingosine-1-phosphate—µmol/L | 1.46 (1.27; 1.73) | 1.47 (1.24; 1.68) | 0.879 |
| Thromboxane B2—pg/mL | 416.9 (133.9; 3338) | 14,580 (4146; 39,718) | < 0.001*** |
| Soluble P-selectin—ng/mL | 125.6 (90.3; 157.4) | 93.6 (62.9; 132.6) | < 0.001*** |
| Symptom onset to blood draw—h | 47.5 (28.3; 92.0) | 42.0 (23.9; 69.0) | 0.104 |
| Medication | |||
| Aspirin—no. (%) | 270 (100) | 0 (0) | |
| ADP receptor inhibitors—no. (%) | 68 (25.2) | 8 (7.7) | < 0.001*** |
| Anticoagulants—no. (%) | 6 (2.9) | 65 (62.5) | < 0.001*** |
| Neurology | |||
| NIHSS—points | 1 (0; 3) | 2 (0; 4) | 0.351 |
| mRS—points | 1 (0; 3) | 1 (0; 3) | 0.887 |