Table 3.
Neutralization of AAV2/7 and AAV2/8 with antisera directed to all serotypes of AAV
| Antisera | Vector
|
|
|---|---|---|
| AAV2/7 | AAV2/8 | |
| AAV1 | <1:20 | <1:20 |
| AAV2 | <1:20 | <1:20 |
| AAV3 | <1:20 | <1:20 |
| AAV4 | <1:20 | <1:20 |
| AAV5 | <1:20 | <1:20 |
| AAV6 | <1:20 | <1:20 |
| AAV7 | 1:160 | <1:20 |
| AAV8 | <1:20 | 1:320 |
Antisera was generated to all known serotypes in the mouse as described in Methods. The ability of these antisera to neutralize AAV2/7 and AAV2/8 vectors is presented in the table: antisera were generated at the University of Pennsylvania for serotypes 1, 2, 5, 7, and 8 and at the University of North Carolina for serotypes 1, 2, 3, 4, 5, and 6.