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. 2002 Aug 14;99(18):11946–11950. doi: 10.1073/pnas.182296499

Figure 3.

Figure 3

VEGF stimulates BrdUrd incorporation into neuroproliferative zones of rat brain in vivo. aCSF (Left) or 10 μg/ml of VEGF (Right) was infused i.c.v. at 1 μl/h and BrdUrd 5′-monophosphate (50 mg/kg) was given i.p. twice daily for 3 days. Four days later, BrdUrd was localized by immunohistochemistry in hippocampus (A) and rostral SVZ (B) (Original magnification, 4×; high-power views of SVZ, 20×). Note that BrdUrd incorporation is not confined to neuroproliferative zones, but extends, for example, into the dentate hilus in (A) consistent with the labeling of both neuronal and non-neuronal (e.g., astroglial) cells (see Fig. 6). Data are representative fields from at least three experiments per panel.