ABTS	2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate)
AGE	advanced glycation end product
AGEs	advanced glycation end products
AG	aminoguanidine
Akt	protein kinase B
BSA	bovine serum albumin
cAMP	cyclic adenosine monophosphate
CREB	cAMP response element-binding protein
Cu2+	copper ion
DEGs	differentially expressed genes
DMEM	Dulbecco’s modified Eagle’s medium
DMSO	dimethyl sulfoxide
DPPH	1,1-diphenyl-2-picrylhydrazyl
EGFR	epidermal growth factor receptor
ERK	extracellular signal-regulated kinase
FBS	fetal bovine serum
FDR	false discovery rate
FPKM	fragments per kilobase of transcript per million mapped reads
GAPDH	glyceraldehyde 3-phosphate dehydrogenase
GM-CSF	granulocyte-macrophage colony-stimulating factor
GO	gene ontology
GSH	glutathione
GSK-3β	glycogen synthase kinase-3 beta
IC50	half-maximal inhibitory concentration
IL-18	interleukin 18
IL-33	interleukin 33
JAK-STAT	Janus kinase-signal transducer and activator of transcription
KEGG	Kyoto Encyclopedia of Genes and Genomes
MAPK	mitogen-activated protein kinase
MC1R	melanocortin 1 receptor
MGO	methylglyoxal
MITF	microphthalmia-associated transcription factor
MMP	matrix metalloproteinase
mRNA	messenger RNA
MSH	melanocyte-stimulating hormone
MTT	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
PBS	phosphate-buffered saline
PCA	principal component analysis
PGE-2	prostaglandin E2
PI3K	phosphatidylinositol 3-kinase
PKA	protein kinase A
PMSF	phenylmethylsulphonyl fluoride
qPCR	quantitative polymerase chain reaction
RNA-seq	RNA sequencing
ROS	reactive oxygen species
SP	Spirulina peptides
TNF	tumor necrosis factor
TRP-1	tyrosinase-related protein 1
TRP-2	tyrosinase-related protein 2
TYR	tyrosinase
UV	ultraviolet
UVB	ultraviolet B