PROTAC	Proteolysis-Targeting Chimera
UPS	Ubiquitin–Proteasome System
E3	E3 Ubiquitin Ligase
CRBN	Cereblon
VHL	Von Hippel–Lindau Protein
MDM2	Mouse Double Minute 2 Homolog
LYTAC	Lysosome-Targeting Chimera
RNA	Ribonucleic Acid
DNA	Deoxyribonucleic Acid
TCGA	The Cancer Genome Atlas
PPIs	Protein–Protein Interactions
AI	Artificial Intelligence
PK/PD	Pharmacokinetics/Pharmacodynamics
CNS	Central Nervous System
TPD	Targeted Protein Degradation
FDA	Food and Drug Administration
IND	Investigational New Drug
SAR	Structure–Activity Relationship
SPR	Surface Plasmon Resonance
ADME	Absorption, Distribution, Metabolism, and Excretion
KEAP1	Kelch-like ECH-associated Protein 1
DCAF16	DDB1- and CUL4-Associated Factor 16
UHRF1	Ubiquitin-like with PHD and RING Finger Domains 1
SCF	Skp1–Cullin–F-box Complex
DUB	Deubiquitinating Enzyme
BRD4	Bromodomain-Containing Protein 4
BCL-xL	B-Cell Lymphoma-Extra Large
CDK	Cyclin-Dependent Kinase
KRAS	Kirsten Rat Sarcoma Viral Oncogene
EGFR	Epidermal Growth Factor Receptor