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. 2026 Jan 30;14(2):316. doi: 10.3390/biomedicines14020316
Amyloid beta
AD Alzheimer’s disease
AKT Protein kinase B
AMPK AMP-activated protein kinase
ATG Autophagy-related genes
ATP Adenosine triphosphate
BCL-2 B-cell lymphoma 2
BCL-xL B-cell lymphoma–extra large
BCR-ABL Breakpoint cluster region–Abelson
CAR-T Chimeric antigen receptor T cell
CCL Chemokine (C-C motif) ligand
CR Caloric Restriction
cAMP Cyclic adenosine monophosphate
CNS Central nervous system
CXCL12 Stromal cell-derived factor 1
D Dasatinib
DNA Deoxyribonucleic acid
DPP-4 Dipeptidyl peptidase-4
eIF5A Eukaryotic translation initiation factor 5A
EPACs Exchange proteins directly activated by cAMP
EPHA2 EPH receptor A2
ER Endoplasmic reticulum
FDA Food and Drug Administration
FKBP12 FK506-binding protein 12 kDa
GABA Gamma-aminobutyric acid
GI Gastrointestinal
GIP Glucose-dependent insulinotropic polypeptide
GLP-1 Glucagon-like peptide-1
GM-CSF Granulocyte-macrophage colony-stimulating factor
gp130 Glycoprotein 130
GRAS Generally recognized as safe
HFD High-fat diet
IBD Inflammatory bowel disease
IGF-1 Insulin-like growth factor 1
IL Interleukin
IL-1 Interleukin-1
IL-1α Interleukin-1 alpha
IL-1β Interleukin-1 beta
IL-6 Interleukin-6
IL-6R Interleukin-6 receptor
JAK Janus kinase
JNK c-Jun N-terminal kinase
MAMPs Microbial-associated molecular patterns
MAPK Mitogen-activated protein kinase
MMP3 Matrix metalloproteinase 3
mTOR Mechanistic target of rapamycin
mTORC1 Mechanistic target of rapamycin complex 1
mTORC2 Mechanistic target of rapamycin complex 2
NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells
NRF2 Nuclear factor erythroid 2–related factor 2
OCT Organic cation transporters
p16 Tumor protein p16
p21 Tumor protein p21
p53 Tumor protein p53
PGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
PI3K Phosphoinositide 3-kinase
PKA Protein kinase A
Q Quercetin
RAP1 Ras-related protein 1
RNA Ribonucleic acid
ROS Reactive oxygen species
SASP Senescence-associated secretory phenotype
SCFAs Short-chain fatty acids
SFB Segmented filamentous bacteria
SGLT2 Sodium-glucose cotransporter 2
STACs Sirtuin activating compounds
SpA Spondyloarthritis
SRC/SFKs SRC family kinases
STAT3 Signal transducer and activator of transcription 3
TFEB Transcription factor EB
TGF-β Transforming growth factor beta
TLR4 Toll-like receptor 4
TMAO Trimethylamine-N-oxide
TNF-α Tumor necrosis factor alpha
TOR Target of rapamycin
VEGF Vascular endothelial growth factor