| WHO | World Health Organization |
| NMDAR | N-methyl-D-aspartate receptor |
| PSD | postsynaptic density |
| GABA | γ-Aminobutyric acid |
| mGluRs | metabotropic glutamate receptors |
| PDZ domains | PSD-95/Disks large/Zonula occludens-1 domains |
| TRS | treatment-resistant schizophrenia |
| PANSS | Positive and Negative Symptoms Scale |
| IP3 | inositol trisphosphate (IP3) |
| DAG | diacylglycerol |
| cAMP | cyclic adenosine monophosphate |
| AMPARs | α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors |
| GPCRs | G protein-coupled receptors |
| GTP | guanosine 5′-triphosphate |
| GDP | guanosine 5′-diphosphate |
| VFD | Venus Flytrap domain |
| LTP | long-term potentiation |
| LTD | long-term depression |
| EVH1 | enabled/vasodilator-stimulated phosphoprotein homology |
| MAP | mitogen-activated protein |
| PIP2 | phosphatidylinositol 4,5-bisphosphate |
| RyR | ryanodine receptor |
| BAR domain | Bin/Amphisin/Rys domain |
| IP3R | inositol triphosphate receptor |
| PSD-95 | postsynaptic density protein 95 |
| COS cells | CV-1 in Origin with SV40 cells |
| GKAP | guanilate-kinase associated protein |
| PLC | phospholipase C |
| PKC | protein kinase C |
| CICR | Ca2+-induced Ca2+ release |
| D2R | dopamine D2 receptor |
| D1R | dopamine D1 receptor |
| PKA | protein kinase A |
| mTORC | mammalian target of rapamycin complex |
| AP5 | 2-Amino-5-phosphonopentanoic acid |
| NO | nitric oxide |
| PFC | prefrontal cortex |
| 5-HT2AR | serotonin 5-hydroxytryptamine 2A receptor |
| SNPs | single-nucleotide polymorphisms |
| GRM3 | glutamate metabotropic receptor 3 gene |
| EAAT2 | excitatory amino acid transporter 2 |
| MRS | magnetic resonance spectroscopy |
| Glx | glutamate + glutamine |
| PCP | phencyclidine |
| NMRI mice | Naval Medical Research Institute mice |
| IκBα | Inhibitor of kappa B alpha |
| ERK1/2 | extracellular signal-regulated kinases ½ |
| Nf-κB | Nuclear Factor kappa-light-chain-enhancer of activated B-cells |
| Hdac2 | histone deacetylase 2 |
| L-BAIBA | L-β-aminoisobutyric acid |
| CA | Cornu Ammonis |
| BBB | blood–brain barrier |
| TMD | heptahelical transmembrane domain |
| CNS | central nervous system |
| CDPPB | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
| NAM | negative allosteric modulator |
| PAM | positive allosteric modulator |
| HPG | 3-Hydroxyphenylglycine |
| CHPG | (R,S)-2-chloro-5-hydroxyphenylglycine |
| DFB | 3,3-difluorobenzaldazine |
| MTEP | 3-((2-Methyl-4-thiazolyl)ethynyl) pyridine |
| MPEP | 2-methyl-6-phenylethynylpyridine |
| BINA | biphenylindanone A |
| GWAS | genome-wide association studies |
| PGC | psychiatric genomic consortium |
| tDCS | transcranial direct current stimulation |
| TMS | transcranial magnetic stimulation |
| DCS | direct current stimulation |