5-HT	5-hydroxytryptamine
7-COOH-CBD	7-carboxycannabidiol
7-OH-CBD	7-hydroxycannabidiol
Aβ	beta-amyloid
AcOEt	ethyl acetate
ACTH	adrenocorticotropic hormone
AE	aqueous extract
Akt	protein kinase B
AUC	area under the plasma concentration curve
BBB	blood–brain barrier
BDI	Beck Depression Inventory
BDNF	brain-derived neurotrophic factor
BuOH	butanol
CBD	cannabidiol
CGI	Clinical Global Impression
CMS	chronic mild stress
CNS	central nervous system
COX-2	cyclooxygenase-2
CPZ	chlorpromazine
CREB	cAMP response element-binding protein
CRH	corticotropin-releasing hormone
CYP	cytochrome P450
Cmax	maximum concentration reached
FAAH	fatty acid amide hydrolase
FST	forced swim test
GABA	gamma-aminobutyric acid
GLU	glutamate
GPx	glutathione peroxidase
GR	glucocorticoid receptor
GSK-3β	glycogen synthase kinase-3beta
HAM-D	Hamilton Depression Rating Scale
HE	ethanol extract
HILI	herb-induced liver injury
HO-1	heme oxygenase-1
HPA	hypothalamic–pituitary–adrenal
Hp-C	conventional Hypericum perforatum
Hp-MF	multi-fractionated Hypericum perforatum
ICAM-1	intercellular adhesion molecule-1
IL-1β	interleukin-1 beta
IL-6	interleukin-6
iNOS	inducible nitric oxide synthase
LPS	lipopolysaccharide
LTP	long-term potentiation
MAGL	monoacylglycerol lipase
MAO	monoamine oxidase
MAPK	mitogen-activated protein kinase
MDA	malondialdehyde
MDD	Major Depressive Disorder
mRNA	messenger ribonucleic acid
NADPH	nicotinamide adenine dinucleotide phosphate
NF-κB	nuclear factor-kappa B
NLRP3	NOD-like receptor family pyrin domain containing 3
NMDA	N-Methyl-D-Aspartate
Nrf2	nuclear factor erythroid 2-related factor 2
NA	Not available
OBX	olfactory bulbectomy
P-gp	P-glycoprotein
PSD-95	postsynaptic density protein 95
ROS	reactive oxygen species
SJW	St. John’s wort
SOD	superoxide dismutase
SSRIs	selective serotonin reuptake inhibitors
SYP	synaptophysin
THC	Δ-9-tetrahydrocannabinol
Tmax	time to maximum concentration
TNF-α	tumor necrosis factor-alpha
TrkB	tropomyosin receptor kinase B
TST	tail suspension test
t½	elimination half-life
UHPLC-MS/MS	ultra-high-pressure liquid chromatography with mass spectrometry
UGTs	uridine 5′-diphospho-glucuronosyltransferases
USA	United States of America
VCAM-1	vascular cell adhesion molecule-1