HEK293T	Human Embryonic Kidney 293T
GFP	Green fluorescent protein
TGR5	Takeda G protein-coupled receptor 5
DMEM	Dulbecco’s modified eagle medium
RT-qPCR	Quantitative reverse transcription polymerase chain reaction
DEGs	Differentially expressed genes
GO	Gene Ontology
KEGG	Kyoto Encyclopedia of Genes and Genomes
PCA	Principal component analysis
FPKM	Fragments Per Kilobase of exon per Million mapped reads
SPR	Surface Plasmon Resonance
CMC	Cell membrane chromatography
cAMP	Cyclic Adenosine Monophosphate
Padj	adjusted p values
GNDC	Gene-encoded Natural Diverse Components Repository
CA	Cholic Acid
RC	Coptis chinensis
TCM	Traditional Chinese medicine
AMPK	Adenosine Monophosphate-Activated Protein Kinase
DMSO	Dimethyl Sulfoxide
FBS	Fetal Bovine Serum
GLP-1	Glucagon-Like Peptide-1
HMOX1	Heme Oxygenase 1