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. 2026 Feb 19;27(4):2000. doi: 10.3390/ijms27042000
TTSPs Type II transmembrane serine proteases
TMPRSS2 Transmembrane protease, serine 2
HAI-1 Hepatocyte growth factor activator inhibitor-1
SPINT1 Serine peptidase inhibitor, Kunitz Type 1
HAI-2 Hepatocyte growth factor activator inhibitor-2
SPINT2 Serine peptidase inhibitor, Kunitz Type 2
HGF Hepatocyte growth factor
HGFA Hepatocyte growth factor activator
MET Mesenchymal–epithelial transition factor
KD1 Kunitz domain 1
KD2 Kunitz domain 2
MANEC Motif at the N-terminus with eight cysteines
PKD Polycystic kidney disease
SCSD Syndromic congenital sodium diarrhea
ER Endoplasmic reticulum
HCC Hepatocellular carcinoma
mRNA Messenger ribonucleic acid
DNMT1 DNA methyltransferase 1
PCa Prostate cancer
GRHL2 Grainyhead-like-2
SMG Submandibular salivary gland
MMP Matrix metalloproteinase
uPA Urokinase-type plasminogen activator
sHAI-1 Soluble HAI-1
HIF Hypoxia-inducible factor (included HIF-1α/2α)
maHAI-1 Membrane-anchored recombinant HAI-1
HAT Human airway trypsin-like protease
EpCAM Epithelial cell adhesion molecule
PAR-2 Protease-activated receptor-2
TROP2 Trophoblast cell surface antigen 2
SNP Single-nucleotide polymorphism
GI Gastrointestinal
SF Scatter factor
E Embryonic day
KD Knockdown
BCT Basal chorionic trophoblast
MT2 Matriptase-2
ENaC Epithelial sodium channel
SOX9 SRY-box transcription factor 9
OA Osteoarthritic
GLP1R Glucagon-like peptide 1 receptor
NPCs Neural progenitor cells
BMP Bone morphogenetic protein
CP Choroid plexus
CPE Choroid plexus epithelial
SIP1 Smad-interacting protein 1
AD Alzheimer’s disease
TAD Thoracic aortic dissection
SMCs Smooth muscle cells
PDGF-BB Platelet-derived growth factor BB
TME Tumor microenvironment
OSCC Oral squamous cell carcinoma
CAF Cancer-associated fibroblast
AML Acute myeloid leukemia
MSCs Mesenchymal stromal cells
SDF-1 Stromal cell-derived factor-1
EMT Epithelial–mesenchymal transition
NSCLC Non-small-cell lung carcinoma
RCC Renal cell carcinoma
LMS Leiomyosarcoma
OS Overall survival
RFS Recurrence-free survival
DMFS Distant metastasis-free survival
HGG High-grade glioma
MB Medulloblastoma