2-HG	D-2-hydroxyglutarate
α-KG	Alpha-ketoglutarate
AAV	Adeno-associated virus
AKT	Protein kinase B
ATRX	ATRX chromatin remodeler
AuNCs	Gold nanoclusters
AuNPs	Gold nanoparticles
AuNRs	Gold nanorods
AV	Adenoviral vectors
BBB	Blood–brain barrier
BTB	Blood–tumor barrier
CAR-T	Chimeric antigen receptor T cells
Cas	CRISPR-associated
Cas9	CRISPR-associated protein 9
CD44	Cluster of differentiation 44
CD8+	Cluster of differentiation 8 positive T cells
CDKN2A/B	Cyclin-dependent kinase inhibitor 2A/2B locus
CHOPCHOP	CRISPR guide RNA design tool
CNS	Central nervous system
crRNA	CRISPR RNA
CRISPOR	CRISPR guide RNA design and off-target prediction tool
CRISPR	Clustered regularly interspaced short palindromic repeats
DSB	Double-strand break
EGFR	Epidermal growth factor receptor
EGFRvIII	Epidermal growth factor receptor variant III
EMT	Epithelial-to-mesenchymal transition
eSpCas9	Enhanced-specificity Streptococcus pyogenes Cas9
FOXG1	Forkhead box G1
GBM	Glioblastoma multiforme
G-CIMP	Glioma CpG island methylator phenotype
GDF15	Growth differentiation factor 15
GO	Graphene oxide
gRNA	Guide RNA
GSCs	Glioma stem-like cells
GSDMD	Gasdermin D
HCAdV	Helper-dependent adenoviral vector
HDR	Homology-directed repair
HDAdV	High-capacity adenoviral vector
HNH	Histidine–asparagine–histidine nuclease domain
HSP90α	Heat shock protein 90 alpha
HTVI	Hydrodynamic tail vein injection
HypaCas9	Hyper-accurate Cas9 variant
IDH1	Isocitrate dehydrogenase 1
IL13Rα2	Interleukin-13 receptor alpha 2
KO	Knockout
LOH	Loss of heterozygosity
LNPs	Lipid nanoparticles
LV	Lentiviral vector
MAP4K4	Mitogen-activated protein kinase 4
MAPK	Mitogen-activated protein kinase
MDSCs	Myeloid-derived suppressor cells
MHC	Major histocompatibility complex
miR	MicroRNA
miR-10b	MicroRNA-10b
miR-21	MicroRNA-21
MGMT	O6-methylguanine-DNA methyltransferase
Mn2+	Manganese (II) ions
MRI	Magnetic resonance imaging
MSH6	MutS homolog 6
MSNs	Mesoporous silica nanoparticles
NHEJ	Non-homologous end-joining
NF1	Neurofibromin 1
NILVs	Non-integrating lentiviral vectors
NIR	Near-infrared
NLS	Nuclear localization signal
PAM	Protospacer adjacent motif
PARP1	Poly(ADP-ribose) polymerase 1
PCSK9	Proprotein convertase subtilisin/kexin type 9
PD-1	Programmed cell death protein 1
PDGFRA	Platelet-derived growth factor receptor alpha
PEG	Polyethylene glycol
PEI	Polyethylenimine
PI3K	Phosphatidylinositol 3-kinase
PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIP2	Phosphatidylinositol-4,5-bisphosphate
PIP3	Phosphatidylinositol-3,4,5-trisphosphate
PTEN	Phosphatase and tensin homolog
RAD51	RAD51 recombinase
RAS	Rat sarcoma GTPase family
REC	Recognition lobe
RNase III	Ribonuclease III
RNP	Ribonucleoprotein
RTKs	Receptor tyrosine kinases
RuvC	RuvC-like nuclease domain
SaCas9	Staphylococcus aureus Cas9
sgRNA	Single-guide RNA
SIN	Self-inactivating
SMNPs	Supramolecular nanoparticles
SNMD	Supramolecular substrate-mediated delivery
SOX2	SRY-box transcription factor 2
SpCas9	Streptococcus pyogenes Cas9
SpCas9-HF1	High-fidelity Streptococcus pyogenes Cas9 variant 1
SPIONs	Superparamagnetic iron oxide nanoparticles
STAT3	Signal transducer and activator of transcription 3
TAMs	Tumor-associated macrophages
TERT	Telomerase reverse transcriptase
TGFβR2	Transforming growth factor beta receptor 2
TME	Tumor microenvironment
TMZ	Temozolomide
TP53	Tumor protein p53
tracrRNA	Trans-activating CRISPR RNA
Tregs	Regulatory T cells
TWIST1	Twist family bHLH transcription factor 1
U87	U87 glioblastoma cell line
VEGF	Vascular endothelial growth factor
VX-765	Caspase-1 inhibitor VX-765
WHO	World Health Organization
WT	Wildtype
ZEB1	Zinc finger E-box binding homeobox 1
ZEBRA	Zwitterionic branched copolymer delivery system