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. 2026 Feb 22;27(4):2049. doi: 10.3390/ijms27042049
AIS Abbreviated Injury Scale
AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
APOE Apolipoprotein E
APP Amyloid Precursor Protein
ASC Apoptosis-associated Speck-like protein containing a CARD
ATP Adenosine Triphosphate
BBB Blood–Brain Barrier
βAPP Beta-Amyloid Precursor Protein
CCI Controlled Cortical Impact
CCL2 C-C Motif Chemokine Ligand 2
CCL3 C-C Motif Chemokine Ligand 3
CCL4 C-C Motif Chemokine Ligand 4
CCR2 C-C Chemokine Receptor Type 2
CD3 Cluster of Differentiation 3
CD4 Cluster of Differentiation 4
CD8 Cluster of Differentiation 8
CD11b Cluster of Differentiation 11b
CD45 Cluster of Differentiation 45
CD206 Cluster of Differentiation 206
cGAS Cyclic GMP-AMP Synthase
CNS Central Nervous System
CSF Cerebrospinal Fluid
CT Computed Tomography
CTE Chronic Traumatic Encephalopathy
DAI Diffuse Axonal Injury
DAMP Damage-Associated Molecular Pattern
DNA Deoxyribonucleic Acid
eNOS Endothelial Nitric Oxide Synthase
ERK Extracellular Signal-Regulated Kinase
ERK1/2 Extracellular Signal-Regulated Kinase 1/2
FAK Focal Adhesion Kinase
FPI Fluid Percussion Injury
GBDPs GFAP Breakdown Products
GCS Glasgow Coma Scale
GFAP Glial Fibrillary Acidic Protein
GPX1 Glutathione Peroxidase 1
GSK-3β Glycogen Synthase Kinase-3 beta
H2O2 Hydrogen Peroxide
HIF Hypoxia-Inducible Factor
HMGB1 High-Mobility Group Box 1
HRP Horseradish Peroxidase
Iba1 Ionized calcium-binding adapter molecule 1
IgG Immunoglobulin G
IL-1β Interleukin-1 beta
IL-1R1 Interleukin-1 Receptor Type 1
IL-1ra Interleukin-1 Receptor Antagonist
IL-4 Interleukin-4
IL-6 Interleukin-6
IL-10 Interleukin-10
IL-15 Interleukin-15
IL-18 Interleukin-18
iNOS Inducible Nitric Oxide Synthase
ISS Injury Severity Score
JNK c-Jun N-terminal Kinase
MAPK Mitogen-Activated Protein Kinase
MCP-1 Monocyte Chemoattractant Protein-1
MMP Matrix Metalloproteinase
MMP-1 Matrix Metalloproteinase-1
MMP-2 Matrix Metalloproteinase-2
MMP-7 Matrix Metalloproteinase-7
MMP-9 Matrix Metalloproteinase-9
MPO Myeloperoxidase
MRI Magnetic Resonance Imaging
mRNA Messenger RNA
NADH Nicotinamide Adenine Dinucleotide (reduced)
NADPH Nicotinamide Adenine Dinucleotide Phosphate
NCLX Mitochondrial Na+/Ca2+ Exchanger
NF-68 Neurofilament-68
NF-κB Nuclear Factor-kappa B
NFL Neurofilament Light
NLRP3 NLR Family Pyrin Domain Containing 3
NMDA N-methyl-D-aspartate
nNOS Neuronal Nitric Oxide Synthase
NO Nitric Oxide
NOS Nitric Oxide Synthase
NOX NADPH Oxidase
NOX1 NADPH Oxidase 1
NOX2 NADPH Oxidase 2
NQO1 NAD(P)H Quinone Dehydrogenase 1
Nrf2 Nuclear Factor Erythroid 2-Related Factor 2
PDE2 Phosphodiesterase 2
Piezo1 Piezo-type Mechanosensitive Ion Channel Component 1
Piezo2 Piezo-type Mechanosensitive Ion Channel Component 2
PMI Post-Mortem Interval
PRX2 Peroxiredoxin 2
PSD-95 Postsynaptic Density Protein 95
PTI Post-Traumatic Interval
RAGE Receptor for Advanced Glycation End-products
RNA Ribonucleic Acid
RNS Reactive Nitrogen Species
ROCK Rho-associated Protein Kinase
ROCK1 Rho-associated Protein Kinase 1
ROS Reactive Oxygen Species
SAP-97 Synapse-Associated Protein 97
SASP Senescence-Associated Secretory Phenotype
SNAP-25 Synaptosome-Associated Protein 25
SOD Superoxide Dismutase
SOD2 Superoxide Dismutase 2
TBI Traumatic Brain Injury
TGF-β Transforming Growth Factor beta
TJ Tight Junction
TLR Toll-Like Receptor
TLR4 Toll-Like Receptor 4
TMEM119 Transmembrane Protein 119
TNF-α Tumor Necrosis Factor alpha
TOS Total Oxidant Status
TRP Transient Receptor Potential
TRX2 Thioredoxin 2
TSPO Translocator Protein
TUNEL Terminal deoxynucleotidyl transferase dUTP nick end labeling
UCH-L1 Ubiquitin Carboxy-terminal Hydrolase L-1
VEGF Vascular Endothelial Growth Factor
VEGFR-2 Vascular Endothelial Growth Factor Receptor 2
ZO-1 Zonula Occludens-1