Fig 4.

AarA can activate EGFr signaling in developing eyes. (a–c and g) Adult compound eyes. (d–f and h) Detail. (a and d) Eye-directed expression of full-length SPI or GRK has no effect on developing eyes. In contrast, coexpression of AarA with SPI (c and f) or GRK (g and h) results in highly compromised compound eyes with malformed and fused ommatidia, closely resembling RHO-1 overexpressing ones (b and e). (i) Tangential sections through adult eyes reveal recruitment of extra photoreceptor neurons (arrow, a m-GRK/AarA eye is shown). (Inset) The wild-type pattern of seven photoreceptor cells normally visible in apical sections.