Fig 1.

Structures of the MYO18B gene and MYO18B protein. (A) Physical and transcriptional maps of the region containing the MYO18B gene. STS markers are marked on the top. Locations of CpG islands and three genes are indicated. The region of homozygous deletion in a SCLC cell line, Lu24, is indicated by a dashed horizontal line. Exon-intron organization of the MYO18B gene is depicted as vertical bars. Predicted transcriptional start and stop sites are indicated by vertical bars under exons 2 and 43, respectively. (B) Schematic diagram of a domain structure of MYO18B protein and positions of mutations in lung cancer cells. Numbers on the top indicate codon numbers. Closed arrowheads, somatic mutations; open arrowheads, base substitutions detected only in cell lines but not in 50 unrelated individuals. Putative functional domains are indicated at the bottom.