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. 2002 Sep 6;99(19):12275–12280. doi: 10.1073/pnas.182418399

Fig 5.

Fig 5.

p572-specific CTL do not lyse activated B lymphocytes. (A) Effector CTL from one of the donors described in Fig. 4D were assayed against autologous B lymphocytes activated for 48 h with trimeric CD40 L (40 μg/ml) (52) and the cell lines indicated, either pulsed or nonpulsed with the p572 peptide. A CTL line originated from pY572-primed HHD mice and maintained by weekly restimulation with p572 (B) or the CTL described in Fig. 2 raised from p572-primed HHD mice (C) were assayed for lytic activity against spleen B lymphocytes from HHD mice incubated with lipopolysaccharide (20 μg/ml) for 48 h and the cell lines indicated, either pulsed or nonpulsed with the p572 peptide. Data represent the percent specific lysis at an E/T ratio of 90:1.