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STAT4 tyrosine and serine phosphorylation are required for normal TH1 differentiation. Purified naive CD4 T cells from STAT4−/− spleen cells were stimulated in the presence of IL-12 and reconstituted with wild-type (wt) and mutant STAT4. The cells were harvested and restimulated with phorbol myristate acetate and ionomycin for intracellular IFN-γ staining.
