Table 2. Amino acid substitutions between Z168, Z296 and the consensus sequences of Chinese Coxsackievirus B4 genotypes A, D and E.

Site		3	5	6	11	64	71	263	271	273	274	277	279	281	283	284
Strain
Genotype A consensus sequence		T	E	S	M	I	S	N	V	A	E	S	I	T	P	Y
Genotype D consensus sequence		T	E	S	M	I	S	N	I	T	K	S	V	T	P	C
Genotype E consensus sequence		T	E	A	M	V	S	N	V	A	E	S	I	T	L	Q
Z168 (genotype D)		A	D	S	I	I	A	N	V	N	E	N	I	T	P	R
Z296 (genotype D)		T	D	S	I	I	A	S	V	T	E	N	I	N	P	R