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. 2026 Feb 19;18(2):257. doi: 10.3390/pharmaceutics18020257
PARPi Poly(ADP-ribose) polymerase inhibitors
NAD+ Nicotinamide adenine dinucleotide
A2AR Adenosine A2A receptor
A2ARa A2AR antagonists
scRNA-seq Single-cell RNA sequencing
cAMP Cyclic adenosine monophosphate
CREB cAMP/cAMP response element-binding protein
ADO Adenosine
TME Tumor microenvironment
PKA Protein kinase A
PBMCs Peripheral blood mononuclear cells
ELISA Enzyme-linked immunosorbent assay
PBS Phosphate-buffered saline
RNA-seq RNA sequencing
TCGA the Cancer Genome Atlas
TCGA-OV the Cancer Genome Atlas-ovarian serous cystadenocarcinoma
FBS Fetal bovine serum
TCIA the Cancer Immunome Atlas
NGS Next-generation sequencing
SD Standard deviation
PCA Principal component analysis
DEGs Differentially expressed genes
GSEA Gene Set Enrichment Analysis
GO Gene Ontology
KEGG Kyoto Encyclopedia of Genes and Genomes
PPI Protein–protein interaction
Tregs Regulatory T cells
Teff Effector T cells
NK cells Natural killer cells
TILs Tumor-infiltrating lymphocytes
GZMB Granzyme B
MDSCs Myeloid-derived suppressor cells
UMAP Uniform Manifold Approximation and Projection
AdenoSig Adenosine gene signature
TAMs Tumor-associated macrophages
IFN-TAMs Interferon-preprocessed TAMs
Reg-TAMs Immune regulatory TAMs
Inflam-TAMs Inflammatory cytokine-rich TAMs
LA-TAMs Lipid-associated TAMs
Angio-TAMs Angiogenic TAMs
Prolif-TAMs Proliferative TAMs
Tn Naive T cells
Th T helper cells
Th1-like Th cells producing interferon-gamma-like
CTLs CD8+ cytotoxic T lymphocytes
MBCs Memory B cells
NBCs Naive B cells
Bregs Regulatory B cells
BCR B cell receptor
SAH S-adenosyl-L-homocysteine
SAHH S-adenosyl-L-homocysteine hydrolase
APCs Antigen-presenting cells
ICI Immune checkpoint inhibitor
TFs Transcription factors