5-FU	5-Fluorouracil
ATCC	American Type Culture Collection
Ara-C	Cytarabine
BRAF	B-Raf proto-oncogene
BRCA1	Breast cancer gene 1
CO2	Carbon dioxide
Ct24	Control cell growth at 24 h
Ct72	Control cell growth at 72 h
DBS	Docking binding score
DHFR	Dihydrofolate reductase
DMAP	4-Dimethylaminopyridine
DMEM	Dulbecco’s Modified Eagle Medium
DMSO	Dimethyl sulfoxide
DNA	Deoxyribonucleic acid
dTMP	2′-Deoxythymidine-5′-monophosphate
dTTP	2′-Deoxythymidine-5′-triphosphate
dUMP	2′-Deoxyuridine-5′-monophosphate
EDCI	Ethyl-3-(3-dimethylaminopropyl)carbodiimide
EGF	Epidermal growth factor
ELISA	Enzyme-linked immunosorbent assay
EMEM	Eagle’s Minimum Essential Medium
FACS	Fluorescence-activated cell sorting
FBS	Fetal bovine serum
FdUMP	5-Fluoro-2′-deoxyuridine-5′-monophosphate
FGFR	Fibroblast growth factor receptor
FITC	Fluorescein isothiocyanate
GI50	Concentration causing 50% growth inhibition
GEM	Gemcitabine
HEPES	4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
IC50	Half-maximal inhibitory concentration
KRAS	Kirsten rat sarcoma viral oncogene homolog
LC-MS	Liquid chromatography–mass spectrometry
MAPK	Mitogen-activated protein kinase
MTT	3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
MTX	Methotrexate
NADPH	Nicotinamide adenine dinucleotide phosphate (reduced form)
NGS	Next-generation sequencing
NIS	N-Iodosuccinimide
NMR	Nuclear magnetic resonance
OD	Optical density
PBS	Phosphate-buffered saline
PDB	Protein Data Bank
PI	Propidium iodide
PI3K	Phosphoinositide 3-kinase
PK	Pharmacokinetics
RMSD	Root mean square deviation
RNA	Ribonucleic acid
RPMI	Roswell Park Memorial Institute medium
SAR	Structure–activity relationship
SG	Sub-G1 phase
SDS-PAGE	Sodium dodecyl sulfate–polyacrylamide gel electrophoresis
SOCl2	Thionyl chloride
TGI	Total growth inhibition
THF	Tetrahydrofolate
TP53	Tumor protein p53
TS	Thymidylate synthase
TYSY	Thymidylate synthase (gene/protein notation)
wt	Wild type