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. 2002 Sep 3;99(19):12345–12350. doi: 10.1073/pnas.192423399

Fig 2.

Fig 2.

Identification of a previously uncharacterized isoform of the DMT1 mRNAs. (A) Sequences of the alternative 5′ regions of the human DMT1 mRNA. The sequences of the two DMT1 variants are identical after reaching the sequence corresponding to exon 2. The specific sequences of each isoform are boxed in blue for the newly identified exon 1 (exon 1A) and in green for the previously described exon 1 (exon1B). (B) Revised genomic organization of the human DMT1 gene. The sequence of the exon 1A has been mapped 1.9 kb upstream of exon 1B in the human genomic sequence (NT-009782). The two 5′ DMT1 variants are generated by alternative promoter usage followed by splicing to exon 2. (C) Alignment of the predicted N-terminal extensions encoded by the exon 1A isoforms of human, mouse, and rat (AF008439) DMT1. Amino acids that are boxed are not conserved in all three species.