2GAS	Recombinant SPBN-based RABV variant carrying two copies of the GAS glycoprotein gene
Acc	Primary astrocytes from the murine corpus callosum
AIF-1	Allograft inflammatory factor 1
AI	Artificial intelligence
ANOVA	Analysis of variance
AraC	Cytosine arabinoside
AUC	Area under the curve
BBB	Blood–brain barrier
BSR	Baby hamster kidney (BSR) cell line expressing T7 polymerase
C1q	Complement component 1q
CCL4	Chemokine (C-C motif) ligand 4
CD3	Cluster of differentiation 3 (T-cell marker)
cc	Corpus callosum
CNS	Central nervous system
Ct	Threshold cycle
Cx	Neocortex
DAMPs	Danger-associated molecular patterns
DAPI	4′,6-diamidino-2-phenylindole
DIV	Days in vitro
DMEM	Dulbecco’s Modified Eagle Medium
DNA	Deoxyribonucleic acid
DNase I	Deoxyribonuclease I
DOG4	Highly pathogenic dog-originated rabies virus strain DOG4
DRV4	Dog rabies virus isolate 4 (original designation of DOG4)
d.p.i.	Days post infection
FAD	Fluorescent antibody dilution buffer
FBS	Fetal bovine serum
FFU	Focus-forming unit
G	Glycoprotein
GAS	RABV G gene carrying the R333E pathogenicity determinant and N194S substitution
GFAP	Glial fibrillary acidic protein
Hpc	Hippocampus
h.p.i.	Hours post infection
IC-LD50	50% intracerebral lethal dose
IFN(-β, -γ)	Interferon (beta, gamma)
IL-1β	Interleukin-1 beta
i.c.	Intracerebral
i.n.	Intranasal
L	RNA-dependent RNA polymerase (large protein)
LOEWE	Initiative for Excellence in Science and Technology of the state of Hessen
M	Matrix protein
m.o.i.	Multiplicity of infection
mGluR2	Metabotropic glutamate receptor 2
NA	Neuroblastoma cell line of A/J mouse origin
nAChR	Nicotinic acetylcholine receptor
NCAM	Neural cell adhesion molecule
N	Nucleoprotein
P	Phosphoprotein
PBS	Phosphate-buffered saline
PCR	Polymerase chain reaction
PEP	Postexposure prophylaxis
qPCR	Quantitative polymerase chain reaction
RABV	Rabies virus
RABVG	Rabies virus genome
RNA	Ribonucleic acid
RNA-seq	RNA sequencing
RNP	Ribonucleoprotein
RPMI	Roswell Park Memorial Institute medium
RT	Reverse transcription
RT-PCR	Reverse transcription polymerase chain reaction
RT-qPCR	Reverse transcription–quantitative polymerase chain reaction
SAD B19	Street Alabama Dufferin B19 rabies virus strain
Sbt	Sorbitol
SELP	P-selectin (endothelial activation molecule)
SEM	Standard error of the mean
SFM	Serum-free medium (OptiPro SFM)
SPBN	Recombinant derivative of SAD B19 with pseudogene deleted and modified G locus
SPBNGA	SPBN variant carrying R333E mutation in G (“GA”)
SPBNGAK	SPBN variant carrying N194K and R333E mutations in G (“GAK”)
SPBNGAS	SPBN variant carrying N194S and R333E mutations in G (“GAS”)
SVZ	Subventricular zone
VNAs	Virus-neutralizing antibodies
WHO	World Health Organization