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. 2026 Feb 13;17:1656377. doi: 10.3389/fendo.2026.1656377

Table 2.

Meta-regression analysis of PMOF in fracture risk assessment in plateau population.

Parameter Category Number of studies Sensitivity (95% CI) P1 Specificity (95% CI) P2
PMOF with BMD (MOFT) Yes 4 0.87 (0.72–1.00) 0.12 0.75 (0.43–1.00) 0.71
No 9 0.56 (0.35–0.78) 0 0.84 (0.67–1.00) 0
Qinghai–Tibetan plateau region (area) Yes 5 0.62 (0.35–0.89) 0.42 0.96 (0.90–1.00) 0.01
No 8 0.73 (0.54–0.92) 0 0.61 (0.40–0.82) 0
The gold standard is fracture (index test) Yes 4 0.81 (0.61–1.00) 0.38 0.78 (0.47–1.00) 0.85
No 9 0.62 (0.40–0.85) 0 0.83 (0.65–1.00) 0
Includes all genders (gender) Yes 7 0.72 (0.52–0.92) 0.94 0.93 (0.84–1.00) 0.02
No 6 0.68 (0.45–0.91) 0 0.59 (0.26–0.91) 0
Cohort study (experimental design) Yes 2 0.71 (0.33–1.00) 0 0.85 (0.52–1.00) 0
No 11 0.69 (0.50–0.89) 0.96 0.81 (0.63–0.98) 0.83

PMOF, probability of major osteoporotic fracture; BMD, bone mineral density.