Table 2.

Altered genes encoding for protein kinases and the corresponding morphology

Involved gene	Histology/tumor type
NTRK1, 2, 3	IFS(-like), IMT, LPF-like, LPF-NT, adult fibrosarcoma, MPNST-like, myopericytoma-like, epithelioid fibrous histiocytoma/superficial ALK-rearranged myxoid spindle cell neoplasm, round cell, epithelioid cell, myxoid neoplasms
EGFR exon 20	FHI, LPF, DFSP-like, myxoid spindle cell neoplasm, congenital peribronchial myofibroblastic tumor
EGFR-KDD	IFS, LPF-like
EGFR rearrangement	LPF/LPF-NT
EGF	LPF/LPF-NT
ALK	IMT, IFS, LPF-like/LPFNT, DFSP-like, 34+ plaque like dermal fibroma, spindle cell/epithelioid/myxoid neoplasms, epithelioid fibrous histiocytoma/superficial ALK-rearranged myxoid spindle cell neoplasm, hemangioma
ROS	IMT, LPF-like/LPFNT, MPNST-like
LTK	IFS-like, MPNST-like, LPF-like/LPF-NT
MET	FHI-like, IFS-like, MPNST-like, LPF-like/LPF-NT
BRAF/RAF1 (cRAF)	IFS-like, fibromatosis-like, IMT-like, MPNST-like, round cells
FGFR1	IFS-like, LPF-like/LPFNT, DFSP-like, biphasic (primitive/spindle cells), epithelioid (files), myxoid, collagenous
ABL	Soft tissue angiofibroma-like, solitary fibrous tumor-like, perineurioma-like
RET	IMT, IFS-like, MPNST-like, LPF-like/LPF-NT, myofibroma-like, MPNST-like, epithelioid fibrous histiocytoma/superficial ALK-rearranged myxoid spindle cell neoplasm, myxoid, epithelioid/round cell neoplasms
PDGFRB	Myofibroma, myopericytoma, dermatomyofibroma, IMT, LPF
IGF1R	IMT

IFS infantile fibrosarcoma, LPF lipofibromatosis, PPF-NT lipofibromatosis-like neural tumor, MPNST malignant peripheral nerve sheath tumor; FHI fibrous hamartoma of infancy, DFSP dermatofibrosarcoma protuberans, IMT inflammatory myofibroblastic tumor