Fig 4.

Hyperphosphorylated tau in 2-month-old mice is localized in the soma of neurons in the entorhinal cortex of AD11 mice (B) with respect to control mice (A). (C) At 2 months of age, the treatment with rhNGF decreases the expression in the soma. (D) The treatment with GAL does not decrease the expression in the soma. At 6 months of age, after a treatment for 2 months, rhNGF partially prevents the abnormal localization of phosphotau in the soma (G) with respect to control (E) and untreated AD11 mice (F). (H) GAL does not prevent the abnormal localization of phosphotau in the soma. At 6.5 months of age, phosphotau is not affected by rhNGF (K) or GAL (L). (J) Phosphotau distribution is comparable to those observed in untreated mice. (I) Control mice do not display labeling for phosphotau in neuronal soma. (Scale bar = 200 μm.)