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. 2002 Aug 30;99(19):12432–12437. doi: 10.1073/pnas.192442999

Fig 5.

Fig 5.

At 2 months of age, APP is localized in the cerebral vessel of AD11 mice (B) with respect to control mice (A). (C) At this age APP increased expression in vessels in AD11 mice is not affected by rhNGF administration. (D) At this age APP increased expression in vessels in AD11 mice is reduced by GAL administration, and staining is comparable to that observed in control mice. Arrows point to APP-positive cerebral vessels. At 6 months of age, APP is extracellularly localized in AD11 mice (F) with respect to age-matched controls (E). After a treatment of 2 months, rhNGF does not influence APP extracellular deposition (G), whereas GAL is effective in decreasing APP extracellular deposition (H). At 6.5 months of age, control mice do not display APP extracellular deposits (I), whereas AD11 mice show them (J). After a treatment for 15 days, rhNGF is unable to rescue APP deposition (K), whereas GAL partially restores APP distribution (L). Arrows point to extracellular deposits of APP. (Scale bar = 200 μm.)