Fig 3.

Locations and time courses of pain-evoked activations. Locations of activations are maxima of mean normalized power maps superposed on a normalized structural T1 weighted magnetic resonance image. Power was normalized to the local power maximum coded in white. For the sake of clarity scaling is different for each area. In the time course profiles light-shaded areas depict early and late time windows with predominantly Aδ fiber-mediated first pain-related and predominantly C fiber-mediated second pain-related activity, respectively. Dark-shaded areas indicate SEM. The dotted lines show 95% confidence intervals of activation for each area. In S1, ipsilateral S2, and ACC in one, two, and four subjects, respectively, no individual power maxima corresponding to the mean power maxima were identified. Thus, calculation of group mean activation time courses in S1, ipsilateral S2, and ACC was based on nine, eight, and six subjects, respectively. S1, primary somatosensory cortex; S2, secondary somatosensory cortex; ACC, anterior cingulate cortex; cl, contralateral; il, ipsilateral.