Fig 2.

Less than 50% of functional α_2A-AR is required for α₂-agonists to elicit hypotension. Mean arterial blood pressure (A–C) and heart rate (D–F) in conscious, freely moving α_2A-AR^+/+ (A and D), heterozygous α_2A-AR^+/− (B and E), and α_2A-AR^−/− (C and F) mice were measured in response to bolus injections of dexmedetomidine (10 μg/kg) into the right jugular vein, defined as time 0, and were followed by a saline bolus wash of the same volume. ↓, Dexmedetomidine infusion. Data are the mean ± SEM of 5 mice per genotype per dexmedetomidine dose.