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Moxonidine-elicited hypotensive responses require expression of the α2A-AR subtype. Mean arterial blood pressure (A and B) and heart rate (C and D) in conscious, freely moving α2A-AR+/+ (A and C), and α2A-AR−/− (B and D) mice were measured in response to bolus injections of moxonidine (300 μg/kg) as in Fig. 2. ↓, Moxonidine infusion. Data are the mean ± SEM of 5 mice per genotype per moxonidine dose.
