Fig 4.

Moxonidine does not cause sedation in α_2A-AR^+/+ mice. Sedative responses to the α₂-agonists UK 14,304, clonidine, moxonidine, or saline were measured as rotarod latency, or the time the mice were able to remain on a rotating bar. (The effects of dexmedetomidine were given in Fig. 1.) UK 14,304 and clonidine (1,000 μg/kg) are sedative in α_2A-AR^+/+ mice, causing these mice to fall from the rotarod bar after 6 and 17 seconds, respectively. In contrast, moxonidine (1,000 μg/kg) is indistinguishable from saline, e.g., nonsedating. *, No sedative response. Time 0 on the rotarod equals, by definition, 100% sedation. Data are the mean ± SEM of 5 α_2A-AR^+/+ mice for each α₂-agonist evaluated.